1 2 3 4 6 8 10 12
Time (weeks)
0
–5
–10
–15
–20
–25
LOCF analysis.
Mean YMRS scores: baseline = 32; endpoint (risperidone) = 11.4
Mean modal dose: risperidone 4.1mg/day; haloperidol = 7.4mg/day
BL = baseline
BL
12-week efficacy in acute mania
Text Box: Mean change in total YMRS score
Mean change in total YMRS score
Risperidone
Haloperidol
(n=90)
(n=64)
Smulevich et al. Eur Neuropsychopharmacol 2005; 15: 75-84.
(Smulevich et al., 2005, p77-9 – Table 2, Figure 2)

Reference
Smulevich AB, Khanna S, Eerdekens M, Karcher K, Kramer M, Grossman F. Acute and continuation risperidone monotherapy in bipolar mania: a 3-week placebo-controlled trial followed by a 9-week double-blind trial of risperidone and haloperidol. Eur Neuropsychopharmacol 2005; 15: 7584.